Synergism between efrotomycin and bottromycin.
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منابع مشابه
Synergism between efrotomycin and bottromycin.
BETTINA M. FROST, MARY E. VALIANT and EUGENE L. DULANEY Merck Institute for Therapeutic Research Rahway, New Jersey, 07065, U.S.A. (Received for publication May 26, 1979) Efrotomycin1) is a narrow spectrum antibiotic which is most active in vitro against representative species of Pasteurella, Moraxella and Corynebacterium2) . The in vivo activity, however, is much better than one would expect f...
متن کاملThe structure of efrotomycin.
The antibiotic efrotomycin (I), C59H88N2O20, was isolated from cultures of Nocardia lactamdurans as an amorphous yellow powder. Mass spectral and NMR analyses show that the compound is a glycoside of the known antibiotic aurodox (II), C44H62N2O12. Ozonolysis and hydrolysis of I produced the disaccharide V, 6-deoxy-4-O-(6-deoxy-2,4-di-O-methyl-alpha -L-mannopyranosyl)-3-O-methyl-beta-D-allopyran...
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Thio-Ugi reactions are described as an excellent synthetic tool for the synthesis of sterically highly hindered endothiopeptides. S-Methylation and subsequent amidine formation can be carried out in an inter- as well as in an intramolecular fashion. The intramolecular approach allows the synthesis of the bottromycin ring system in a straightforward manner.
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1979
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.32.1046